Abstract: Ten treatments designed by Random Blocks were used to study the effect of various base fertilizer applications on the yield and quality of butterbur on a medium fertility land.The results showed that (a) With a constant top dressing, the vegetable yield increaded with the increased fertilization within a certain range; (b) Taking economic factors into consideration, the application of ChaoDa Bio-organic Fertilizer at the rate of 2 400 kghm-2 as the base fertilizer produced an optimal result; (c) The contents of soluble sugars, soluble protein and crude fiber increased initially and decreased afterwards with the application of organic and inorganic fertilizers; (d) Application of organic fertilizer reduced, while inorganic fertilizer increased, the nitrate content; and, (e) Application of ChaoDa Bio-organic Fertilizer at the rate of 2 400 kghm-2 as the base fertilizer and AoLaiTe Fertilizer at the rate of 1 200 kghm-2 as the top dressing were found to be optimal for high yield and improved quality of butterbur on land of medium fertility grade.