Abstract: The effects of three fungicide combinations on the control of the susceptible potato cultivars/varieties Favorite were investigated, including Metalaxyl-M mancozeb (68% WG) , Antracol propineb (70% WP) and Oxadixyl mancozeb (64% WP) .Our results showed that the controlling effect of the combination of two or three fungicides is better than a single one.After the alternative application of Metalaxyl-M mancozeb (68% WG) and Antracol propineb (70% WP) , Antracol propineb (70% WP) and Oxadixyl mancozeb (64% WP) , Metalaxyl-M mancozeb (68% WG) and Oxadixyl mancozeb (64% WP) for four times, the control effects were reached 65.96%, 61.70%and 60.34% and the yields were increased by 61.74%, 60.07% and 52.01% respectively.Our results suggest that alternately application of fungicids will be benefit for the control of late blight.