诺氟沙星在奥尼罗非鱼体内的药代动力学及残留研究

廖碧钗

诺氟沙星在奥尼罗非鱼体内的药代动力学及残留研究

廖碧钗^1,2

1.
福建省淡水水产研究所,福建福州 350002;
2.
福建省水产技术推广总站,福建福州 350003

基金项目:

福建省海洋与渔业厅重点项目(2009 1-15);国家现代农业产业技术体系建设项目(CARS-49);福建省种业创新与产业化工程项目(2011FJZY);公益性行业(农业)科研专项(200803013)

详细信息

作者简介:
廖碧钗(1982-),女,硕士,主要从事水产病害防控和水产品质量安全研究(E-mail:liaobichai@163.com)

中图分类号: S 859.84
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出版历程
- 收稿日期: 2011-01-13
- 修回日期: 2011-06-02
- 刊出日期: 2011-12-14

Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia

LIAO Bi-chai^1,2

1.
The Freshwater Fisheries Research Institute of Fujian Province,Fuzhou, Fujian 350002, China;
2.
Fujian Fishery Technical Extension Center,Fuzhou, Fujian 350003, China

摘要

摘要: 在水温(252)℃条件下,以20 mgkg-1鱼体重的剂量给奥尼罗非鱼单次口灌诺氟沙星,高效液相色谱法测定血浆和肌肉组织中的药物浓度,研究诺氟沙星在奥尼罗非鱼体内的代谢及消除规律。结果显示:血药时间数据符合一级吸收二室开放模型,半衰期(T1/2Ka、T1/2、T1/2)分别为1.30、1.97、26.36 h,最大血药浓度为0.546 g mL-1,达峰时间为2.715 h,药时曲线下面积(AUC)为14.491 gh mL-1。选取肌肉组织作为残留检测的靶组织,以10 gkg-1为最高残留限量,在本试验条件下,建议休药期不低于55 d。
- 诺氟沙星 /
- 奥尼罗非鱼 /
- 药代动力学 /
- 残留
Abstract: In order to study the metabolism and elimination of norfloxacin (NFX) in hybrid tilapias (Oreochromis aureusO.niloticus), single oral administration at dose of 20 mgkg-1 had been investigated in healthy tilapia at (252)℃.The result demonstrated: Plasma concentration-time datas of NFX were best fitted using a two-compartmental open model.Absorption, distribution and elimination half-life were 1.30,1.97 and 26.36 hours, respectively.The maximal plasma concentration was 0.546 gmL-1, peaking at 2.715 hour.Area under the plasma drug concentration-time curve was 14.491 ghmL-1.As an edible tissue, muscle was selected as target tissue in this experiment.The maximum residue limit (MRL) is 10 gkg-1 in muscle, the withdrawal time should not be less than 55 days under this experiment condition.
- norfloxacin /
- hybrid tilapia /
- pharmacokinetics /
- residues