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Volume 26 Issue 6
Feb.  2012
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Article Contents
LIAO Bi-chai. Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia[J]. Fujian Journal of Agricultural Sciences, 2011, 26(6): 930-934.
Citation: LIAO Bi-chai. Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia[J]. Fujian Journal of Agricultural Sciences, 2011, 26(6): 930-934.

Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia

  • Received Date: 2011-01-14
  • Rev Recd Date: 2011-06-03
  • Publish Date: 2011-12-15
  • In order to study the metabolism and elimination of norfloxacin (NFX) in hybrid tilapias (Oreochromis aureusO.niloticus), single oral administration at dose of 20 mgkg-1 had been investigated in healthy tilapia at (252)℃.The result demonstrated: Plasma concentration-time datas of NFX were best fitted using a two-compartmental open model.Absorption, distribution and elimination half-life were 1.30,1.97 and 26.36 hours, respectively.The maximal plasma concentration was 0.546 gmL-1, peaking at 2.715 hour.Area under the plasma drug concentration-time curve was 14.491 ghmL-1.As an edible tissue, muscle was selected as target tissue in this experiment.The maximum residue limit (MRL) is 10 gkg-1 in muscle, the withdrawal time should not be less than 55 days under this experiment condition.
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