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CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.
Citation:
CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.
CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.
Citation:
CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.
An attenuated vaccine strain of Duck Paramyxovirus(DPMVa) was selected and obtained by passage serial within SPF chicken embryo fibroblast(CEF), and some biological property of it were detemined. The DPMVa was non-pathogenic to Muscovy ducks without maternal antibody; and was non-viulence through five serial passages in one-day-old Muscovy ducks; TCID50 to CEF stable between 10-6.0~10-6.5·(0.1 mL)-1. The protection rate of the attenuated strain was above 90% when challenged with a virulent strain of DPMV 7 days after vaccination. The results indicated that attenuated vaccine strain had excellent safety, effective immunogenicity and genetic stability, which could be used as a vaccine against DPMV.
NEROME K,SHIBATA M,KOBAYASHI S,et a1.Immunological and genomic analyses of two serotypes of avian paramyxovirus isolated from wild duck in Japan [J].J Virol,1984,50(2):649-653.