Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria

LIU Xiao-long; LAI Long-yong; TAN Li-ning; LIU You-lin; XU Lei; WU Chang-biao; YANG Shou-shen; YANG Hui; YU Xun-xin; CHENG Long-fei; HUANG Yu

doi:10.19303/j.issn.1008-0384.2019.05.010

Volume 34 Issue 5

Aug. 2019

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Article Navigation > Fujian Journal of Agricultural Sciences > 2019 > 34(5): 575-580

LIU Xiao-long, LAI Long-yong, TAN Li-ning, LIU You-lin, XU Lei, WU Chang-biao, YANG Shou-shen, YANG Hui, YU Xun-xin, CHENG Long-fei, HUANG Yu. Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria[J]. Fujian Journal of Agricultural Sciences, 2019, 34(5): 575-580. doi: 10.19303/j.issn.1008-0384.2019.05.010

Citation:

LIU Xiao-long, LAI Long-yong, TAN Li-ning, LIU You-lin, XU Lei, WU Chang-biao, YANG Shou-shen, YANG Hui, YU Xun-xin, CHENG Long-fei, HUANG Yu. Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria[J]. Fujian Journal of Agricultural Sciences, 2019, 34(5): 575-580. doi: 10.19303/j.issn.1008-0384.2019.05.010

Citation:

LIU Xiao-long, LAI Long-yong, TAN Li-ning, LIU You-lin, XU Lei, WU Chang-biao, YANG Shou-shen, YANG Hui, YU Xun-xin, CHENG Long-fei, HUANG Yu. Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria[J]. Fujian Journal of Agricultural Sciences, 2019, 34(5): 575-580. doi: 10.19303/j.issn.1008-0384.2019.05.010

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Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria

doi: 10.19303/j.issn.1008-0384.2019.05.010

1.
Present(Fuzhou) Biotech Co., Ltd., Fuzhou, Fujian 350500, China
2.
Fujian Vocational College of Agriculture, Fuzhou, Fujian 350303, China
3.
Nanjing Tianbang Bio-industry Company Limited, Nanjing, Jiangsu 211102, China
4.
Fujian Vocational College of Agriculture, Fuzhou, Fujian 350007, China
5.
College of Life Sciences, Longyan University, Longyan, Fujian 364012, China
6.
Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China

Received Date: 2019-02-14
Rev Recd Date: 2019-04-15
Publish Date: 2019-05-28

Abstract

Abstract

Objective Activity of porcine antibacterial peptides (PAP) against avian Salmonella and Escherichia coli was determined for drug development. Method Inhibitive activity of PAP on avian pathogens was studied in vitro on an liquid medium and by an in vivo test. Results PAP at a concentration of 1.0 mg·mL^-1 showed a higher bacteriostatic effect on the solution contaning 10⁶ CFU·mL^-1 of the pathogens than at 0.5, 0.2 or 0.1 mg·mL^-1. Compared with 15 antibiotics, such as amoxicillin, erythromycin, tetracycline, etc., PAP induced the largest inhibition zone on the growth of avian Salmonella FJS13 and E. coli FJE61. In a challenging test on chicken, the PAP administration improved the survival rate of the subcutaneous injected birds. Conclusion PAP could be used as a bioagent to combat the infection on chickens by avian Salmonella and E. coli.
- porcine antibacterial peptide,
- antibacterial activity,
- inhibition,
- avian Salmonella,
- avian Escherichia coli,
- chicken

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References(16)

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