Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection

CHEN Shi-long; XIAO Shi-feng; CHENG Xiao-xia; LIN Feng-qing; WANG Shao; WANG Jin-xiang; ZHU Xiao-li; CHEN Shao-ying

doi:10.19303/j.issn.1008-0384.2017.011.004

Volume 32 Issue 11

Jan. 2018

Turn off MathJax

Article Contents

Article Navigation > Fujian Journal of Agricultural Sciences > 2017 > 32(11): 1189-1192

CHEN Shi-long, XIAO Shi-feng, CHENG Xiao-xia, LIN Feng-qing, WANG Shao, WANG Jin-xiang, ZHU Xiao-li, CHEN Shao-ying. Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection[J]. Fujian Journal of Agricultural Sciences, 2017, 32(11): 1189-1192. doi: 10.19303/j.issn.1008-0384.2017.011.004

Citation:

CHEN Shi-long, XIAO Shi-feng, CHENG Xiao-xia, LIN Feng-qing, WANG Shao, WANG Jin-xiang, ZHU Xiao-li, CHEN Shao-ying. Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection[J]. Fujian Journal of Agricultural Sciences, 2017, 32(11): 1189-1192. doi: 10.19303/j.issn.1008-0384.2017.011.004

Citation:

CHEN Shi-long, XIAO Shi-feng, CHENG Xiao-xia, LIN Feng-qing, WANG Shao, WANG Jin-xiang, ZHU Xiao-li, CHEN Shao-ying. Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection[J]. Fujian Journal of Agricultural Sciences, 2017, 32(11): 1189-1192. doi: 10.19303/j.issn.1008-0384.2017.011.004

PDF( 1258 KB)

Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection

doi: 10.19303/j.issn.1008-0384.2017.011.004

Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences/Fujian Animal Diseases Control Technology Development Center, Fuzhou, Fujian 350013, China

Received Date: 2017-07-15
Rev Recd Date: 2017-09-20
Publish Date: 2017-11-28

Abstract

Abstract

In this paper, an experimental concentrated inactivated vaccine and a conventional inactivated vaccine against Novel Duckling Reovirus (NDRV) infection were prepared. After one single-dose immunization in adult Cherry Valley ducks, the serum samples collected in a period of 13 weeks were tested for antibodies by serum neutralisation (SN) method. The protective effects against NDRV infection were observed in 3-day-old Cherry Valley ducklings and mule duckling after a single-dose immunization. The serological results showed that concentrated inactivated vaccine was much more immunogenic than the conventional inactivated vaccine, with a much higher SN antibody titers at all test time points. The concentrated inactivated vaccine was highly protective against NDRV challenge at 7-day post-vaccination with a 100% protective efficacy, as compared to 40%-60% protective efficacy for conventional inactivated vaccine. Taken together, this experimental concentrated inactivated vaccine exhibited immune efficiency much superior to conventional inactivated vaccine and might be a useful vaccine against NDRV infection.
- Novel Duck Reovirus infection,
- concentrated inactivated vaccine,
- conventional inactivated vaccine,
- efficacy evaluation

FullText(HTML)

References(7)

References

[1]	陈少莺, 陈仕龙, 林锋强, 等.一种新的鸭病(暂名鸭出血性坏死性肝炎)病原学研究初报[J].中国农学通报, 2009, 25(16):28-31. http://www.cnki.com.cn/Article/CJFDTOTAL-ZJNB201406010.htm
[2]	陈仕龙, 陈少莺, 程晓霞, 等.新型鸭呼肠孤病毒分离株的致病性研究[J].西北农林科技大学学报:自然科学版, 2010, 38(4):14-18. http://d.old.wanfangdata.com.cn/Conference/7295811
[3]	陈少莺, 陈仕龙, 林锋强, 等.新型鸭呼肠孤病毒的分离与鉴定[J].病毒学报, 2012, (3):224-230. http://www.cnki.com.cn/Article/CJFDTOTAL-BDXB201203008.htm
[4]	陈仕龙, 李兆龙, 林锋强, 等.新型鸭呼肠孤病毒病灭活疫苗的制备及免疫原性分析[J].福建农业学报, 2012, 27(5):461-464. http://www.fjnyxb.cn/CN/abstract/abstract1905.shtml
[5]	程晓霞, 陈少莺, 林锋强, 等.番鸭呼肠孤病毒弱毒疫苗在番鸭体内中和抗体消长规律的研究[J].福建农业学报, 2014, 29(1):5-7. http://www.fjnyxb.cn/CN/abstract/abstract2338.shtml
[6]	殷震, 刘景华.动物病毒学:第2版[M].北京:科学出版社, 1997:336-339.
[7]	刘源远.灭活疫苗中抗原浓缩对有效预防家禽主要传染病的重要性[J].养禽与禽病防治, 2004, (10):37-38. http://www.cqvip.com/qk/92765X/200410