Abstract: It was reported that the controlling effects on panicle blast by hybrid rice in different match were more than 22.55% and increased yield by 14.3 kg/mu. Our demonstrative result using mix-culture of Diyou 64 with Weiyou 64 in different match showed that the optimum match was 1:1 mix-culture of these two cultivars, which the controlling effect reached 55.81%～66.01%, and the yield increased more than 14.6%. The mechanism of mix-culture to control the rice blast was primarily explored. It was found that the chief physiological races in mix-culturing plots were mainly ZC group which occupied 69.76%, In contrast, the single-culturing plots were mainly ZB group and occupied 64.70%, The tentative conclusion of this experiment was that,the mix-culture has a certain interference to the pathogenicity of Pyricularia oryzae and decreases their function,thus lightened the harmness from the pathogen.